2021


The protein N-terminal acetyltransferase A complex contributes to yeast mitophagy via promoting expression and phosphorylation of Atg32.  Mitsutaka Kubota, Koji Okamoto

J. Biochem. 170(2):175-182  2021 (PMID:34115119 DOI:10.1093/jb/mvab068



Mitochondrial dynamics and degradation in the oleaginous yeast Lipomyces starkeyi. Lan Duan, Koji Okamoto

Genes Cells 26(8):627-635  2021 (PMID:34085353 DOI:10.1111/gtc.12875


2020


Detection of mitophagy in mammalian cells, mice, and yeast. Calvelli Hannah, Krigman Judith, Onishi Mashun, Narendra Derek P, Sun Nuo, Okamoto KojiMethods in Cell Biology 155 557 - 579 2020年


2019


Repression of mitochondrial metabolism for cytosolic pyruvate-derived chemical production in Saccharomyces cerevisiae. Morita Keisuke, Matsuda Fumio, Okamoto Koji, Ishii Jun, Kondo Akihiko, Shimizu HiroshiMicrobial Cell Factories 18(1) 177 - 177 2019年10月15日 



The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy. Zheng Liangde, Shu Wen-Jie, Li Yu-Min, Mari Muriel, Yan Chaojun, Wang Dehe, Yin Zhao-Hong, Jiang Wei, Zhou Yu, Okamoto Koji, Reggiori Fulvio, Klionsky Daniel J, Song Zhiyin, Du Hai-NingAutophagy 1 - 14 2019年9月19日 


A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy. Murakawa Tomokazu, Okamoto Koji, Omiya Shigemiki, Taneike Manabu, Yamaguchi Osamu, Otsu KinyaCell Reports 26(2) 338 - 345 2019年1月  


2018


Mitochondrial stasis reveals p62-mediated ubiquitination in Parkin-independent mitophagy.

Yamada T, Murata D, Adachi Y, Itoh K, Kameoka S, Igarashi A, Dawson TM, Yanagawa T, Okamoto K, Iijima M, *Sesaki H.

Cell Metab., 28(4):588-57 (2018).

The TORC1 signaling pathway regulates respiration-induced mitophagy in yeast.

Liu Y, *Okamoto K.

Biochem. Biophys Res Commun. , doi: 10.1016/j.bbrc.2018.04.114(2018).


The ER membrane insertase Get1/2 is required for efficient mitophagy in yeast.

Onishi M, Nagumo S, Iwashita S, *Okamoto K.

Biochem. Biophys Res Commun., doi: 10.1016/j.bbrc.2018.05.123 (2018).

The Nem1-Spo7 protein phosphatase complex is required for efficient mitophagy in yeast.

Xu X, *Okamoto K.

Biochem. Biophys Res Commun., 496(1):51-57 (2018).

<Reviews, Proceedings and Books>


Phosphatidic acid and cardiolipin coordinate mitochondrial dynamics.

Kameoka S, Adachi Y, Okamoto K, Iijima M, *Sesaki H.

Trends Cell Biol., 28: 67-76. (2018).

分解標識タンパク質が駆動するミトコンドリア特異的オートファジー

*岡本浩二

DOJIN NEWS, No. 165, 7-9., ISSN 0385-1516 (2018).

2017


Investigation of Yeast Mitophagy with Fluorescence Microscopy and Western Blotting.

Nagumo S, *Okamoto K.

Methods Mol Biol., doi: 10.1007/7651_2017_11 (2017).

Assays for Mitophagy in Yeast.

Eiyama A, *Okamoto K.

Methods Mol Biol., 1567:337-347. (2017)

<Reviews, Proceedings and Books>


ミトコンドリア分別・除去システムの基本原理

*岡本浩二

The Frontiers in Life Sciencesシリーズ、「オートファジー」, 113-123., ISBN 978-4-525-13481-5 (2017).

2015


Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling

Sakakibara K, Eiyama A, Suzuki SW, Sakoh-Nakatogawa M, Okumura N, Tani M, Hashimoto A, Nagumo S, Kondo-Okamoto N, Kondo-Kakuta C, Asai E, Kirisako H, Nakatogawa H, Kuge O, Takao T, Ohsumi Y, *Okamoto K.

EMBO J. 34: 2703-2719. (2015)

<Reviews, Proceedings and Books>


Preface - The special issue on mitophagy.

*Okamoto K.

Biochim. Biophys. Acta 1853: 2755. (2015)

PINK1/Parkin-mediated mitophagy in mammalian cells.

Eiyama A, *Okamoto K.

Curr. Opin. Cell Biol. 33: 95-101.(2015)

2014


Enhancement of ethanol fermentation in Saccharomyces cerevisiae sake yeast by disrupting mitophagy function.

Shiroma S, Jayakody LN, Horie K, Okamoto K, *Kitagaki H.

Appl. Environ. Microbiol.80: 1002-1012.(2014)


<Reviews, Proceedings and Books>


Receptor-mediated mitophagy in yeast and mammalian systems.

Liu L, Sakakibara K, *Chen Q, *Okamoto K.

Cell Res. 24: 787-795.(2014)


Assays for autophagy II: Mitochondrial autophagy.

*Kanki T, Okamoto K.

Methods Mol. Biol. 1163: 165-173.(2014)

出芽酵母が語る選択的ミトコンドリア分解の基本原理.

*岡本浩二.

医学のあゆみ・AYUMI「マイトファジー―基礎から疾患との関連まで」 250: 483-487.(2014)


2013


Mitochondrial degradation during starvation is selective and temporally distinct from bulk autophagy in yeast.

Eiyama A, Kondo-Okamoto N, *Okamoto K.

FEBS Lett. 587: 1787-1792.(2013)


<Reviews, Proceedings and Books>


No ATG is an island - the connection of autophagy with diverse pathways and functions.

*Komatsu M, Kuma A, Okamoto K.

EMBO Rep. 14: 219-221.(2013)



2012


Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy.

Kondo-Okamoto N, Noda NN, Suzuki SW, Nakatogawa H, Takahashi I, Matsunami M, Hashimoto A, Inagaki F, Ohsumi Y, *Okamoto K .

J. Biol. Chem.287: 10631-10638.(2012)


<Reviews, Proceedings and Books>


Mitochondria and autophagy: critical interplay between the two hemostats.

Kondo-Okamoto N, *Okamoto K.

Biochim. Biophys. Acta 1820: 595-600.(2012)


マイトファジーの分子機構.

*岡本浩二

DOJIN BIOSCIENCE SERIES 04,「オートファジー」. 133-149.(2012)


ミトコンドリア品質管理研究の最前線.

*岡本浩二

細胞 THE CELL 44: 45-48.(2012)


2011


Structure-function analysis of the yeast mitochondrial Rho GTPase, Gem1p: implications for mitochondrial inheritance.

Koshiba, T., Holman, H.A., Kubara, K., Yasukawa, K., Kawabata, S., Okamoto, K., MacFarlane, J., Shaw, J.M.

J. Biol. Chem. 286: 354-362. (2011)


<Reviews, Proceedings and Books>


Mitochondria breathe for autophagy.

Okamoto, K.

EMBO J. 30: 2095-2096.(2011)


Mitochondria autophagy in yeast.

Kanki, T., Klionsky, D.J., Okamoto, K.

Antioxid. Redox Signal.14:1989-2001.(2011)

2010


<Reviews, Proceedings and Books>


酵母のマイトファジー〜観察からの始まり〜.顕微鏡

岡本徳子,岡本浩二,大隅良典

45: 83-86.(2010)

マイトファジー:ミトコンドリアを丸ごと分別・除去する仕組み.細胞工学・特集「その時ミトコンドリアは動いた」

岡本浩二*,岡本徳子

細胞工学・特集「その時ミトコンドリアは動いた」29: 423-428.(2010)

2009


Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy.

Okamoto, K.*, Kondo-Okamoto, N., and Ohsumi, Y.*

Dev. Cell,17: 87–97.(2009)


<Reviews, Proceedings and Books>


A landmark protein essential for mitophagy. Autophagy,

Okamoto, K.*, Kondo-Okamoto, N., and Ohsumi, Y.*

Autophagy, 5: 1203-1205.(2009)


2008


TPR proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis.

Kondo-Okamoto, N., Shaw, J.M., and Okamoto, K.*

EMBO rep., 9: 63-69.(2008)


Multiple pathways influence mitochondrial inheritance in budding yeast.

Frederick, R.L., Okamoto, K., and Shaw, J.M.

Genetics, 178: 825-837.(2008)

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